| 초록 |
Herein, we report that horseradish peroxidase (HRP) initiates the polymerization of catecholic precursors, resulting in local generation of brown-to-black pigments on HRP-printed area. Given the contribution in natural adhesive systems, catecholic moieties in these pigments seems to drive the localization on the surface with HRP without diffusion to solution. By a conventional ink-jet printing of HRP, we successfully fabricated HRP-guided polycatecholic pigments in various shapes and different intensity. It was observed that cells were well-attached on the fabricated pigment and showed good biocompatibility. In addition, the fabricated pigment showed efficient photothermal conversion enabling site-specific cell death by near-infrared irradiation. We expect this simple biofabrication method will be applicable to generate biointerface on a variety of biosensing devices and cell-based bioassays. |
