| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
NIR and temperature responsive release property of dipalmitoylphosphatidylcholine liposomes incorporating hydrophobically modified thiolated-carboxymethyl cellulose-capped gold nanoparticles and hydrophobically modified poly(N-isopropylacrylamide) |
| 초록 |
Dipalmitoylphosphatidylcholine (DPPC) liposome was surface-decorated with hydrophobically modified poly(N-isopropylacrylamide) (Hm PNIPAM), and gold nanoparticle (GNP) that capped with hydrophobically modified thiolated carboxymethylcellulose (Hm TL-CMC). GNP was prepared using Hm TL-CMC as a reducing agent for gold ions and a capping material for GNP. Film hydration and sonication method was used for preparing DPPC liposomes incorporating Hm TL-CMC-capped GNP and Hm PNIPAM and they have a multi lamellar structure along with GNP on its TEM micrograph. The temperature-responsive release profile of DPPC liposome was much higher when the liposome was incorporating Hm PNIPAM than control DPPC liposome. it may due to the thermal contraction of the polymer chains. NIR-responsive release property was shown in DPPC liposome incorporating Hm TL-CMC-capped GNP. It possibly due to the photothermal effect of GNP, and when the liposome was bearing Hm PNIPAM, the NIR-responsive release was enhanced. |
| 저자 |
박영민, 자오, 김진철
|
| 소속 |
강원대 |
| 키워드 |
Liposome; Thiolated carboxymethylcellulose; Gold nanoparticle; Near-infrared; Responsive release
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| E-Mail |
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