| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 | 28권 1호, p.115 |
| 발표분야 | 고분자 합성 |
| 제목 | Synthesis and Characterization of Biodegradable Poly(ethylene galactarate)(PEGa) |
| 초록 | Recently, bioabsorbable polymers that have side functional groups have been much studied as drug carriers and scaffolds for tissue engineering due to their biodegradability and biocompatibility. During the last three decades, various polyfunctional bioabsorbable polymers were tried to synthesize; amongst those polymers, polyhydroxypolyamides and polyesteramides have been reported possible from the reaction between sugar derivatives and diamines, However, these polyamides were criticized in that they might cause some unexpected troubles in the process of bioabsorption due to the presence of amide bonds, and have somewhat slow hydrolytic degradation rate. This may be one reason why polyalkanoates that are polyesters, e.g. PLA, predominant the polymeric materials for biomedical applications. In this respect, if polyhydroxypolyesters could be prepared, then those would be expected to be used as biodegradable drug carriers or scaffolds that can modulate the cellular response in tissue engineering due to crosslinking capability of polyhydoxyl groups. It is however that polyhydroxypolyesters have not been reported as yet. In this study, we tried to synthesize for the first time the polyhydroxypolyesters by reacting a monosaccharide, galactaric acid, with ethylene glycol To avoid complicated protecting-deprotecting steps in the synthesis, we tried direct polycondensation of one or two stages. Polymerization behavior was monitored as functions of conversion, molecular weight change, catalytic effects, etc, using various techniques such as FTIR, 1H-NMR, elemental analysis, GPC, etc. |
| 저자 | 주상기;박종래 |
| 소속 | 서울대 |
| 키워드 | direct esterification; transesterification |
