| 초록 |
Among the supramolecular nanostructured systems based on the self-assembly of block molecules, rigid-flexible peptide building blocks are one of the most attractive candidates for tissue engineering, regenerative medicine, and drug delivery applications. To meet the rapidly growing needs for new medical scaffolds and the fields of nanotechnology and nanoscience, we synthesized Multifunctional peptide amphiphiles with the rolls of target-selectivity and therapy. They can not only have the target-selective epitopes, but also encapsulate hydrophobic fluorescent dyes within the self-aggregate cores such as spheres, fibrils and vesicles. We have investigated the aqueous self-assembling behaviors of rigid-flexible peptides (RFP) by using dynamic light scattering (DLS), circular dichroism (CD), and transmission electron microscopy (TEM). We believe that this approach presents a very attractive strategy to construct new generation of multifunctional nanoparticles for biomedical applications. |
