| 학회 | 한국화학공학회 |
| 학술대회 | 2006년 가을 (10/27 ~ 10/28, 고려대학교) |
| 권호 | 12권 2호, p.1423 |
| 발표분야 | 공업화학 |
| 제목 | Property and release behavior of ibuprofen-loaded poly(D,L-lactide-co-glycolide) nanoparticles prepared by the emulsification-diffusion method |
| 초록 | Polymer nanoparticles have shown much promise in controlled release and targeted drug delivery. Among them, biodegradable polymer nanoparticles, such as PLGA(poly(D,L-lactide-co-glycolide)), were more preferable candidate for drug delivery system (DDS). In this study, PLGA nanoparticles containing drugs were prepared by the emulsification-diffusion method and ibuprofen was used as a model drug. The emulsification-diffusion method has been used successfully to prepare naanoparticles from preformed polymers in an efficient and reproducible manner. It involves the formation of a conventional oil-in-water emulsion within a partially water-soluble solvent. The subsequent addition of water to the system makes the organic solvent diffuse into the external phase, resulting in the formation of nanoparticles. The size distribution of ibuprofen-loaded PLGA nanoparticles was measured by particle size analyzer. Also, the drug encapsulation efficiency and the release behavior were analyzed by UV-Visible spectrometer. |
| 저자 | 이호석, 조경인, 송기창, 최은정, 안양규 |
| 소속 | 건양대 |
| 키워드 | PLGA; drug; emlsion |
| 원문파일 | 초록 보기 |
