| 학회 | 한국화학공학회 |
| 학술대회 | 2006년 가을 (10/27 ~ 10/28, 고려대학교) |
| 권호 | 12권 2호, p.1363 |
| 발표분야 | 고분자 |
| 제목 | Cell specific targeting PLGA - hyaluronic acid (HA) complex as drug carrier for cancer therapy: in vitro study |
| 초록 | This work has an objected to advance a HA-PLGA conjugated nanoparticle for cancer therapy that effective targeted and drug released breast cancer cell. Polymeric prodrug was prepared as a model drug carrier and HA was surface conjugated to grant receptor mediated targeting moiety to express CD44 of breast cancer cell lines. HA was successfully conjugated on PLGA nanoparticle these chemically conjugated HA-PLGA nanoparticles were compared to the ones prepared by nanoprecipitation. In comparison with HA-PLGA/np, HA-PLGA/conj nanoparticles exhibited superior colloidal stability and higher HA fixation amount. We demonstrated that for both HA-PLGA/conj and HA-PLGA/np. Furthermore, HA-PLGA/conj was more efficiently bind to CD 44 receptors than that of HA-PLGA/np. The drug release profiles of HA-PLGA nanoparticles showed more sustained drug release in comparison to pure PLGA nanoparticles without distinct difference between HA-PLGA/conj and HA-PLGA/np. This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (R15-2004-024-00000-0) and (R01-2006-000-10023-0), Republic of Korea. |
| 저자 | 형우찬, 함승주 |
| 소속 | 연세대 |
| 키워드 | Hyaluronic acid; Conjugated Nanoparticle; Specific targeting; CD44 antibody; Targeted Drug delivery |
| 원문파일 | 초록 보기 |
