| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Targeted Delivery of Paclitaxel by Folate-conjugated Heparin-based Self-assembled Nanoparticle |
| 초록 |
We synthesized the folate-conjugated heparin/poly(β-benzyl-L-aspartate) (PBLA) amphiphilic copolymers (HPs) with or without a poly(ethlylene glycol) linker as paclitaxel (PTX) carriers. PTX was incorporated into heparin nanoparticles at a high drug loading content by a simple dialysis method. The size of PTX-loaded nanoparticles was in the range of 140-190 nm, which indicated the potential capacity for targeting solid tumor tissues passively by the Enhanced Permeability and Retention (EPR) effect. In vitro drug release test revealed that these PTX-loaded nanoparticles displayed sustained drug release patterns. Confocal image analysis revealed that folate-conjugated nanoparticles exhibited far greater extent of cellular uptake than the nanoparticles without folate ligands against KB cell. They also showed higher toxicity against tumor cells than PTX itself and folate-unconjugated nanoparticles. |
| 저자 |
이립1, 이용규2, 허강무1, 김소연1
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| 소속 |
1충남대, 2충주대 |
| 키워드 |
drug delivery; nanoparticle; paclitaxel; active targeting
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| E-Mail |
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