| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
약물 및 유전자 전달용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Nanobiomaterials for wound-healing treatments |
| 초록 |
Nanofibrous meshes with different morphology was prepared and surface-modified with different growth factors for wound healing treatments. Chitosan-Pluronic gel was photocrosslinked to encapsulate epidermal growth factor for wound healing treatments. Released amount of the surface-immobilized growth factor was minimal while the core-encapsulated growth factor was release out in a burst release manner. Epidermal growth factor encapsulated in the hydrgel showed a sustained release profile for prologned period of time. The immobilized and encapsulated growth factor were shown to exert proliferation effects in vitro. Keratinocytic differentiation was significant when epidermal growth factor was employed. In vivo experiment also confirmed wound healing efficacy of the growth factor immobilized nanobiomaterials. |
| 저자 |
유혁상, 최지숙, 박신영, 김혜성, 정현아
|
| 소속 |
강원대 |
| 키워드 |
nanofiber; wound healing; EGF; FGF
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| E-Mail |
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