| 초록 |
Polymer nanoparticles have been developed as smart nanocarriers for cancer therapy. However, they have several requirements for successful cancer therapy which are robust structure in systemic blood circulation and facilitated drug release within the target tissue. Recent studies suggested that coordination bond between Fe3+ and catechol ligand is only slightly weaker than a covalent bond and has pH-responsive reversible association/dissociation property. As pH increases from 5 to 7.4, the complex of catechol-Fe3+ changes from mono-complex to bis-complex. In this work, we aim to develop pH-responsive polymer nanoparticles (CLPNs) of PEG-b-poly(L-3,4-dihydroxy phenylalanine) (PEG-PDOPA) copolymer, in which the PDOPA core was cross-linked by Fe3+. This CLPN can hold the drug at physiological pH and can release the drug in acidic condition. |
