| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Application of Dendritic Gold Nanoparticle for Efficient siRNA Delivery System and Gene Silencing |
| 초록 |
Small interfering RNA (siRNA) delivery system has been one of therapeutic strategies in RNA interference (RNAi) by sequence-specifically silencing target gene. However, a rigid double-stranded structure of siRNA hinders the formation of tight complex with conventional cationic carriers. Therefore, stabilized siRNA/carrier complexes are required to support an efficient siRNA delivery. In this study, dendritic gold nanoparticles (Au@MCs) were synthesized by using polymeric micelles. The stable encapsulation of siRNA was enhanced both by ionic interaction and physical interaction with Au@MCs. As a result, the siRNA/Au@MCs contributed to serum stability and improved gene silencing effect. |
| 저자 |
김다훤, 임수연, 김이슬, 정재백, 김동민, 조희주, 정지훈
|
| 소속 |
성균관대 |
| 키워드 |
small interfering RNA; gold nanoparticles; stabilizing polymeric micelles; gene silencing
|
| E-Mail |
|
