| 초록 |
As we enter into an aging society around the world, patients with laryngeal atrophy and dysfunction are increasing. Patients with decreased laryngeal function have symptoms of voice change, dysphagia, and aspiration pneumonia. Although laryngoplasty has been widely performed for dysfunctions of larynx, it cannot recover intrinsic functions of larynx. Thus, we fabricated an injectable alginate/hyaluronic acid hydrogel loading bFGF for inducing rejuvenation of aged laryngeal muscle. After 1 month and 3 months of injecting the hydrogel into laryngeal muscle of 18-month-old rat, rejuvenation efficacy of the bFGF-loaded hydrogel was evaluated by qPCR, histology, and a high speed camera. bFGF-loaded hydrogel induced an increase in expression of myogenic regulatory factor-related genes, hypertrophy of muscle fiber, proliferation of muscle satellite cells, and angiogenesis. Therefore, bFGF-loaded alginate/hyaluronic acid hydrogel can be a candidate for laryngoplasty with therapeutic effect. |
