| 초록 |
Bone healing is one of the importance phenomena in clinical fields, including oral, maxillofacial, orthopedic, and plastic surgery. In general, the rapid appearance of connective in bone defect during healing which lead to the incomplete bone formation is considered as a major limitation in bone regeneration. To solve this problem, guide bone regeneration (GBR) membranes which can prevent connective tissue infiltration into the bone defect, and thus allow sound bone regeneration has been utilized in clinical practices. In this study, we prepared an unique GBR membrane with leaf-stacked structure which may meet the essential requirements of GBR membrane as well as allow sustained release of bioactive molecules (i.e. BMP-2). Their morphology, mechanical property, wettability and BMP-2 release profile were characterized. And the osteogenic differentiation potential of periosteum-derived cells on the BMP-2-loaded GBR membrane was also investigated. |
