| 초록 |
Recently, the injection laryngoplasty technique for the regeneration of vocal fold have gained popularity because of its initial low cost, minimal invasiveness, and low morbidity as compared to surgical repair method. A number of injectable substances have been adapted in the clinical practice, however, relatively short-term volume stability, inflammation, granuloma formation, and decreased vocal fold vibration are considered as limitations for practical use. In this study, we fabricated a dual growth factors (HGF and bFGF)-loaded polycaprolactone (PCL) microspheres/hydrogel system, which can provide a maintenance of initial bulking effect and sequential delivery of growth factors. A relatively fast release is required for bFGF being released from hydrogel and a sustained release is critical for HGF being released from polycaprolactone (PCL) microspheres for effective vocal fold augmentation. |
