| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Porous Beads with Leaf-Stacked Structure as a Practical Carrier for Bioactive Molecules |
| 초록 |
To reconstruct damaged tissues or organs, several strategies using cells, scaffolds, and bioactive molecules have been explored. In recent, bioactive molecules-loaded scaffolds which can allow controlled release of bioactive molecules as well as provide a frame for cell adhesion/growth/differentiation are considered as a first-line tool for target tissue/organ regeneration. To introduce the bioactive molecules on certain matrices, surface modifications based on physicochemical reaction are commonly utilized. However, the potential toxicity of chemical residue used for the surface modification is considered as a major huddle for clinical applications. In this study, we developed a porous bead with leaf-stacked structure which can allow sustained release of bioactive molecules without any chemical reactions. The morphology, BMP-2 release profile and induction potential for osteogenic differentiation of the BMP-2-loaded porous bead were estimated. |
| 저자 |
김호용1, 박진호2, 변준호2, 이진호3, 오세행1
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| 소속 |
1단국대, 2경상대, 3한남대 |
| 키워드 |
Porous beads; sustained release; osteogenic differentiation
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| E-Mail |
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