| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Sprayable and Injectable Gelatin Hydrogels with a Broad Range of Stiffness |
| 초록 |
Previously, we have reported injectable gelatin-PEG-tyramine hydrogel by enzymatic cross-linking for tissue regeneration. In this study, new injectable gelatin (100%) hydrogels have been prepared by using gelatin derivatives with various phenolic contents, which have been synthesized by coupling hydroxyphenyl propionic acid (HPA) and tyramine (TA). The physico-chemical properties of GHPA-TA hydrogels were characterized and mechanical strength revealed a broad range of stiffness (2,220-30,580 Pa). The evaluation of tissue adhesive on porcine skins showed the controllable adhesive strength (15-25 kPa) by changing phenolic contents. The obtained results demonstrate the effect of cross-linking density in hydrogels and gelatin hydrogels have a great potential as a sprayable and injectable adhesive matrix for biomedical applications. |
| 저자 |
이윤기1, 배진우1, 박경민2, 박기동1
|
| 소속 |
1아주대, 2Johns Hopkins Univ. |
| 키워드 |
Gelatin hydrogel; Enzymatic cross-linking; Tissue regeneration
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| E-Mail |
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