| 초록 |
We developed a drug delivery system based on a redox-sensitive polymer dot (PD) for diagnosing cancer. BODIPY and Paclitaxel, loaded into PD are released via disulfide-thiol conversion in response to high GSH amount in cancer cells. Paclitaxel selectively released in the cancer cell environment, enabling killing that showed 100% release at 10 mM GSH. The quenching effect caused by BODIPY loading is interfered by GSH, subsequently release BODIPY; hence, the death of cancer cells can be visually monitored. Confocal images confirmed cellular uptake in MDCK, HeLa, and MDAMB cells for drug release and bio-imaging. This fluorescence on-off system allows the development of a matrix that can be used as a selective nanocarrier for killing cancer cells by showing a distinction between normal cells and cancer cells in response to GSH levels. This work was supported by Korea National University of Transportation in 2019. |
