| 학회 |
한국화학공학회 |
| 학술대회 |
2009년 가을 (10/22 ~ 10/23, 일산 KINTEX) |
| 권호 |
15권 2호, p.1567 |
| 발표분야 |
생물화공 |
| 제목 |
Study of Cellular Uptake and In Vivo Tumor Accumulation of PLGA-Based Nanoparticles with Functionalized Surface Hydrogel Layers |
| 초록 |
The PLGA nanoparticles with chitosan- or heparin-functionalized surface hydrogel layers were prepared to overcome their intrinsic limitation of relatively low tumor accumulation. Both bare control and the functionalized nanoparticles had serum stability and negligible cytotoxicity to normal and tumor cells. However, the markedly enhanced cell uptake and in vivo tumor accumulation were observed by the functionalized nanoparticles, compared to control. These results show the evidence of a positive effect of the surface functionalization of nanoparticle on in vivo tumor accumulation for the case of a hard, PLGA nanoparticle system, which could be strongly related with an improved intracellular uptake. ***This research was partially supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (MEST) of Korea (R15-2008-006-02002-0), and by the World Class University (WCU) program at GIST through a grant provided by MEST, Korea (R31-2008-000-10026-0). |
| 저자 |
정용일1, 김종철1, 김영하1, 태기융1, 이승영2, 김광명2, 권익찬2
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| 소속 |
1광주과학기술원, 2한국과학기술(연) |
| 키워드 |
Tumor accumulation; PLGA nanoparticle; Heparin; Chitosan
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| E-Mail |
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| 원문파일 |
초록 보기 |
