| 초록 |
Poly(D,L-lactic acid) or poly(glycolic acid) or it’s copolymers were used to fabricate various porous biodegradable scaffold for tissue engineering and drug delivery. A variety of methods how been reported to fabricate porous scaffolds but TIPS has some distinct features. TIPS have two basic mechanisms, the interference between a liquid-liquid demixing process in a polymer solution and a solidification process by virification or crystallization. We blend the PLLA with PLGA to prepare biodegradable poly(L-lactic acid) (PLLA)/poly(L-lactic acid-co-glycolic acid) (PLGA) composite scaffold by thermally induced separation (TIPS) using dioxane as a solvent, water as a non-solvent. The tissue engineering scaffold, a macroporous open celluar structure is required with pore size of 100-300mm for cell penetration. For systems undergoing phase separation by high-interconnected, macroporous structure with nearly uniform pore size, then freezing and solvent removal can result in a significant increase in pore size. Pore size was controlled by quench depth, coarsening time and using for a PEG-PLGA diblock. The porous morphology of produced scaffold was characterized by scanning electron microscopy (SEM). |
