| 초록 |
We designed a polyethylenimine (PEI)-passivated fluorescent polydopamine (FDA-PEI) for fluorescent-based bacteria sensing and photothermal-based antibacterial agent. Polydopamine was carbonized using strong acid to produce fluorescent polydopamine (FDA), and passivated using PEI to provide positive charge for bacteria sensing. FDA-PEI interacted with negatively-charged bacteria cell wall due to the presence of positive charge on FDA-PEI surface, causing fluorescent quenching of FDA-PEI. In addition, catechol moieties on FDA-PEI provided adhesive property to make surface-coatable probe which had similar performance on bacteria sensing compared with aqueous-phase assay. Moreover, this nanoparticle showed photothermal heat under NIR irradiation and trigger photothermolysis of bacterial cell. Thus, this system offers synergistic detection and killing of bacteria which are simple, rapid, versatile and effective. This work was supported by Korea National University of Transportation in 2018. |
