| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
The Synthesis and Sol-gel Transition Behavior of the Comb-like PEG-PLGA Block copolymer |
| 초록 |
Amphiphilic block copolymers having stimuli-sensitivity are well established for the potential application as the drug carrier and copolymers of PEG and polyester have been studied by many researchers. The properties of block copolymers can be modified by introducing various segments. In this research, Poly(N-isopropylacrylamide) (PNIPAAm) which had LCST behavior at 32℃ and polyacrylamide which showed pH sensitivity were used to synthesize comb-like block copolymer containing amphiphilic block. Amphiphilic PLGA block copolymer was prepared by ring opening polymerization of DL-lactide and glycolide with PEGMA or MPEG. Synthesized multi-branched copolymer showed temperature or temperature/pH sensitivity according to backbone material. The molecular weight and chemical structure of synthesized copolymer with various compositions were confirmed by GPC and NMR, and sol-gel transition was tested by tube-tilting method. |
| 저자 |
유지은, 김성철
|
| 소속 |
한국과학기술원 |
| 키워드 |
Amphiphilic block copolymers; sol-gel transition; PNIPAAm; PAAm
|
| E-Mail |
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