| 학회 |
한국화학공학회 |
| 학술대회 |
2007년 가을 (10/26 ~ 10/27, 한국과학기술원) |
| 권호 |
13권 2호, p.1284 |
| 발표분야 |
고분자 |
| 제목 |
Magnetic Resonance Contrast Agents for Cancer Imaging using PEG-Fatty Acid |
| 초록 |
Diagnosis of cancer in the early stages requires sensitive magnetic resonance (MR) probes to detect low concentrations of magnetic substances. In this study, ultrasensitive magnetic resonance contrast agents (UMRCAs) composed of magnetic nanocrystals and amphiphilic block copolymers were synthesized for cancer detection using polyethylene glycol and fatty acid. The chemical structures and the compositions of PEGylated magnetic nanoparticles were analyzed. UMRCAs displayed remarkable colloidal stability and high sensitivity as MR probes. Furthermore, UMRCAs exhibited low cytotoxicity and excellent cancer detection ability in an in vivo animal model. |
| 저자 |
양재문, 임은경, 서성백, 윤호근, 서진석, 허용민, 함승주
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| 소속 |
연세대 |
| 키워드 |
MRI; nanoprobe; magnetic nanocrystals; PEG; fatty acid
|
| E-Mail |
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| 원문파일 |
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