| 초록 |
Recently, external stimuli-responsive controlled-delivery vectors are highly advantageous in gene delivery due to minimal side effects. Among various external stimuli, light provides a safe and convenient opportunity to release gene timely and site-specifically, which is considered to enhancing gene delivery efficiency. Photothermal effect also can be used as one of transfection strategy using light, which is called as ‘photothermal transfection’. Graphene Oxide (GO) has attracted increasing interest for its potential of applications in biomedical fields such as biological imaging, drug/gene delivery and cancer therapy. Herein, we developed nanosized, reduced graphene oxide sheets with covalently conjugation of branched polyethyleneimine and polyethylene glycol and confirmed the potential of locally and remotely activated photothermal transfection in cells using PEG-BPEI-rGO with NIR irradiation. Gene transfection as well as physicochemical properties will be presented in this study. |
