| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Regeneration of tendon-to-bone interface using BMP-2 loaded hydrogel |
| 초록 |
The distinctive structure of the tendon-bone junction is important for the effective transmission of mechanical force between soft tendon and hard bone, composed of a tendon, noncalcified fibrocartilage, calcified fibrocartilage, and bone. In this study, we focused on the regeneration of this interface in the porous rod-type PLCL scaffold, seeding tenocytes and fibrochondrocytes at each designated part separately. Especially, BMP-2 and fibrochondrocytes were loaded together in the heparin-based hydrogel and expected to induce the formation of fibrocartilage transition zone. After 2 months of tissue culture, regeneration at interface was evaluated concerning how well the specific characteristics of interfacial tissues were expressed. |
| 저자 |
이종만1, 최원일1, 태기융1, 김영하1, Vincenzo Guarino2, Luigi Ambrosio3
|
| 소속 |
1광주과학기술원, 2Institute for Composite & Biomedical Materials, 3Italy |
| 키워드 |
Tendon; Tissue engineering; PLCL
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| E-Mail |
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