| 초록 |
Poly(ethylene glycol)(PEG) polymers are non-toxic, water soluble, chemically stable, and resistant to immune response that have potential applications in biomedicine and pharmaceutical areas. The introduction of PEG into the star-shape structure, it has different structure, for example smaller hydrodynamic volume and spherical shape, may has additional advantages compared to linear PEG. Star-shape polymers are synthesized using varying polymerization methods, however, anionic polymerization is the most powerful method to obtain well defined structure. We synthesized star-shape PEG using anionic ring opening polymerization by core first method which defined molecules are formed from activated core monomers using diphenylmethyl potassium(DPMK) as deprotonating agent in DMSO. At the end of star-shape PEG, functional terminal groups are introduced such as amine instead of hydroxyl that leads to applications for biomedical field. |
