| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
대학원생 구두발표 (영어발표, 발표15분) |
| 제목 |
Non-invasive optical imaging of the cascade of events during angiogenesis in mouse hindlimb ischemia models |
| 초록 |
Angiogenesis, which has been an important target for disease diagnosis and therapy, is comprised of a series of events. In the early stage of angiogenesis, the expression of VEGFR and the ECM-deteriorating activities of proteases such as MMP are upregulated. Thus, imaging both events is vital in monitoring the initial process of angiogenesis. Here, we synthesized and characterized two imaging probes which are based on a VEGFR-binding peptide and a MMP-degradable peptide. The probes were used together to visualize and qualitatively measure the VEGFR expression and the MMP activities in mouse hindlimb ischemia models with induced angiogenesis. The combined time-lapse images were employed for the spatio-temporal comparison of the cascade of events during angiogenesis. The non-invasive visualization of the first series of events in angiogenesis indicated that the location of the over-expression of VEGFR changes subsequently following the increased MMP activity in the ischemic region. |
| 저자 |
박수빈1, 박재형2, 권익찬1, 김광명2, 김선화2
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| 소속 |
1성균관대, 2한국과학기술(연) |
| 키워드 |
Angiogenesis; VEGFR; MMP; Hindlimb ischemia
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| E-Mail |
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