| 초록 |
In the past, extensive efforts have been made to control the growth direction and the spacing of neovessels because of their critical roles in homeostasis, pathogenesis and regeneration of tissue. However, no success has been achieved to regulate the physiologically relevant micro-scale spacing between functional neovessels through which blood flows, and this has been a grand challenge for tissue engineers and biomedical scientists for many years. Here, we present a novel strategy for constructing a new living microvascular stamp which releases multiple angiogenic factors and subsequently creates neovessels with the same micrometer scale pattern as that engraved in the stamp using a stereolithographic assembly unit. Thus, controlling the ‘bottom-up’ emerging behavior of the neovessel formation via 'directed top-down’ cues using the living microvascular stamp is a major step forward to better understand vascular biology and also improve quality of a variety of clinical treatments necessitating the neovascularization. |
