| 초록 |
Nanobiosensor has been selected as a method for detecting wide range of pathogens to prevent pandemic emergence. As one of promising platform, conductive polymer based nanobiosensor has a distinct advantage in the way that its ability to sensitive and rapid detection. In this study, we designed a detection system which is conductive poly (aniline-co-pyrrole) based on polymersome conjugated with peptide for specific recognition of influenza A virus. We synthesized poly (aniline-co-pyrrole) polymerized within a polymersome consisting of methoxy polyethylene glycol-block- polyphenylalanin co-polymer (mPEG-b-pPhe). Then we conjugated the polymersome with peptide binding to hemagglutinin located on the surface of influenza virus. In the presence of Influenza virus, the nanoparitlce aggregated with the virus, exposing absorption wave length change. These results indicate that this nanobiosensor could be a potential candidate in terms of detecting influenza virus. |
