| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 |
20권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
NONOates-Loaded Block Copolymer Templated Mineralized Nanoparticles for Intracellular Nitric Oxide Delivery |
| 초록 |
Nitric oxide (NO) has been known as an important molecule in controlling apoptosis of cancer cells. In these days, mineralized nanoparticles based on block copolymer templates have shown efficient loading potential of therapeutics and delivery ability to target disease sites. In this study, we are heading to develop a NONOates-loaded mineralized nanoparticle (NONOates-MNP) that can intracellularly deliver nitric oxide. The NONOates-MNP was prepared by CaCO3 mineralization using NONOates-incorporated poly(ethylene glycol-b-polyethyleneimine) (PEG-b-PEI) block copolymer as templates. At physiological pH, the CaCO3 core phase of the MNP would effectively protect NONOates. In contrast, at an endosomal acidic pH, NONOates would be exposed to an aqueous environment as CaCO3 core phase degrades, thereby releasing nitric oxide (NO) molecules at the cytoplasm. NONOates-loaded MNP can be used as a novel intracellular NO-releasing nanocarrier for nitric oxide-mediated cancer chemotherapy. |
| 저자 |
이대환1, 김다은1, 이홍재1, 정서영1, 최형우2, 김원종2, 이상천1
|
| 소속 |
1경희대, 2포항공과대 |
| 키워드 |
Nitric oxide; NONOate; Cancer; Block copolymer; Mineralization; Calcium carbonate; Nanoparticle
|
| E-Mail |
|
