| 초록 |
Theranostic nanoparticles equipped with the dual functions of the simultaneous diagnosis and treatment of disease have played an important role in the improvement of cancer treatment. We aim to develop a theranostic agent based on doxorubicin (DOX)-loaded MnCO3 nanoparticles (DOX-MnCO3 NPs) that can generate CO2 bubbles and Mn2+ ions for US imaging and T1 Imaging, respectively, and simultaneously release DOX for cancer treatment. At physiological pH (7.4), the DOX-MnCO3 NPs would not show noticeable US and T1 MR contrast signals. In contrast, at tumoral pH (6.4), they may generate strong echogenic signals due to CO2 bubble generation and T1 signals caused by the release of Mn2+ ions. Besides, at tumoral pH, the DOX-MnCO3 NPs would effectively release DOX for cancer treatment. This activatable theranostic agents may find a broad applicability due to improved diagnostic and therapeutic activity for various cancers. |
