| 초록 |
Surface Enhanced Raman Scattering (SERS) has been of great interest to advance highly sensitive biosensors based on optical detection. Especially, clustered metallic nanoparticles as SERS nanotags are important to detect specific biological moieties with ultra-sensitivity because of increased hot spots. In this study, we report that cluster formation of gold nanoparticles (GNPs) were mediated by graphene oxide (GO) to develop a new class of SERS nanotags for biosensing. GNPs with Raman reporters were first modified with hydrophobic moieties and subsequently complexed with nanosized GOs via hydrophobic interactions, resulting in formation of SERS nanotags with controlled size. GO-induced aggregation of GNPs significantly increased SERS signal higher than individual GNPs due to electromagnetic enhancement at the interstices of GNP clusters. Synthesis, characterization, and optimization of these SERS nanotags could open a new avenue for SERS-based biosensing applications. |
