| 학회 |
한국공업화학회 |
| 학술대회 |
2010년 가을 (10/27 ~ 10/29, 대전컨벤션센터) |
| 권호 |
14권 2호 |
| 발표분야 |
정밀화학 |
| 제목 |
Preparation of Novel Photo-labile Linker and Its Application to Solid-phase Peptide Synthesis |
| 초록 |
The role of linker is very important in solid-phase peptide synthesis (SPPS). Its cleavage condition must be orthogonal to the synthetic conditions of peptides. Photo-labile linkers are cleaved under certain photonic conditions and make themselves very useful tools in on-bead enzyme assay because of their orthogonal performance to both of acid-labile and base-labile condition. But the existing photo-labile linkers have some weaknesses such as difficulty in synthesis or poor kinetic performance.Herein, we prepared N-Fmoc-3-amino-3-(3,4-dimethoxy-6-nitrophenyl)propionic acid from 6-veratraldehyde in 6 steps in high yield and analyzed its photo-cleavage condition and kinetic performance. |
| 저자 |
경산, 김재희, 신동식, 이윤식
|
| 소속 |
서울대 |
| 키워드 |
photo-labile linker; SPPS
|
| E-Mail |
|
