| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_정밀화학 |
| 제목 |
Synthesis of Curcumin Derivatives for β–amyloid Plaques Optical Imaging |
| 초록 |
Curcumin is a natural product with a variety of biological potential and high photoluminescenes. The extracellular deposition of β–amyloid (Aβ) is considered to be a major pathological property of Alzheimer’s disease(AD) brain and the most significant target for molecular imaging. A visualization of cerebral β-amyloid plaques is the most feasible way to diagnose AD. Recently, it has been suggested that the Alzheimer’s peptide, Aβ, accumulates in the eye. In particular, the rigid conjugated planarity compounds fit into hydrophobic binding channels of Aβ plaques easily. In this study, PEGylated curcumin derivatives were synthesized for binding to Aβ plaques with high photoluminescence and blood circulation. In comparison with Thioflavin S, dye used for histology staining of amyloid, our synthesized PEGylated curcumin derivatives showed high intensity in APP/PS1 mice (AD model) ex vivo staining. |
| 저자 |
유수아1, 김동욱1, 안희수2, 이교철2, 이용진2
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| 소속 |
1인하대, 2원자력의학원 |
| 키워드 |
Curcumin; Alzheimer's diesease; Imaging
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| E-Mail |
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