| 학회 |
한국화학공학회 |
| 학술대회 |
2010년 가을 (10/21 ~ 10/22, 대전컨벤션센터) |
| 권호 |
16권 2호, p.1546 |
| 발표분야 |
생물화공 |
| 제목 |
Synthesis and Characterization of Thermo-Sensitive Pluronic-Based Nano-Carriers for Tumor Targeting |
| 초록 |
Thermo-sensitive Pluronic-based nano-carriers(NCs) were designed for targeting tumors. Bare forms of thereNCs consisted of Pluronic F 68 or F 127, whereas chitosan-conjugated forms consisted of Chito-NC 68 or Chito-NC 127. TheNCs did not cause any cytotoxicity when cultured with normal NIH3T3 fibroblasts or tumor SCC7 cells. The in-vivo accumulation of thereNCs in tumors was optically monitored using Cy5.5-modifiedNCs in SCC7 tumor-bearing mice. Higher accumulation of chitosan-modified NCs was seen compared to the bareNCs forms. Even though the bareNCs accumulated well in the tumor site, they were rapidly excreted. Therefore, we believe that conjugation of Pluronic-basedNCs with chitosan plays a significant role in effective targeting of tumors. Acknowledgement : This research was supported by BasicScience research Program through theNRF of Korea founded by the MEST of Korea (R15-2008-006-02002-0), and by the WCU program at GIST through a grant provided by MEST, Korea (R31-2008-000-10026-0). |
| 저자 |
이종현1, 최원일2, 김자영1, 김영하1, 태기융1, 이승영3, 김광명3, 권익찬3
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| 소속 |
1광주과학기술원 신소재공학과 및 나노바이오재료전자공학과, 2광주과학기술원 신소재공학과 및 나노바이오재료전자공학과, 3KIST |
| 키워드 |
pluronic; thermo-sensitive; chitosan; tumor specific targeting
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| E-Mail |
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| 원문파일 |
초록 보기 |
