| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis of retinoic acid-loaded poly(NIPAM-co-AA) for cancer therapy |
| 초록 |
We synthesized thermo-responsive poly(NIPAM-co-AA) composite polymers containing retinoic acid. This thermo-responsive polymer with the lower critical solution temperature (LCST) was easily polymerized with hydrophilic or hydrophobic monomers. The synthesized N-isopropylacrylamide and acrylic acid composite polymer (poly(NIPAM-co-AA)) were used for the delivery and controlled release of retinoic acid. It demonstrated that thermo-responsive polymer, poly(NIPAM-co-AA), showed 37℃ LCST in an aqueous solution. The shape and synthesis of poly(NIPAM-co-AA) was analyzed by transmission electron microscope (TEM) and nuclear magnetic resonance (NMR). Therefore, this retinoic acid-loaded thermo-responsive polymer could be a potential nanocarrier for the drug delivery and cancer therapy applications. |
| 저자 |
구보람, 김지은, Gulfam Muhammad, 정봉근
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| 소속 |
한양대 |
| 키워드 |
Poly(NIPAM-co-AA); Hyperthermia; Thermo-responsive polymer
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| E-Mail |
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