| 학회 |
한국화학공학회 |
| 학술대회 |
2005년 봄 (04/22 ~ 04/23, 여수대학교) |
| 권호 |
11권 1호, p.136 |
| 발표분야 |
공업화학 |
| 제목 |
Highly controlled drug release on silicified L3-poly(N-isopropylacryl amide) gels integrated hydroxyapatite for hard tissue therapy |
| 초록 |
The hydroxyapatite porous scaffolds with silicified L3-poly(N-isopropylacrylamide) gels by the integration of thermosensitive hybrid polymer have been prepared and demonstrated the highly controlled drug release for hard tissue therapy over a longer period of time due to the high degree of continuity in 3-D interconnected porous structure of silicified L3-phase and HA. The silicified L3 (sponge) phase gels based on liposome structure have been prepared, which allows the fabrication of L3-PNIPAm gels by integration of thermosensitive polymer with high degree of continuity and contigunity in the pore and the network walls. A nanodiffusion mechanism affected by the polymer shrinkage and 3-D interconnected pores is proposed to achieve a remarkable thermo-sensitive on-off regulation for IMC delivery on L3-PNIPAm gels. |
| 저자 |
조민애1, 박무언2, 장정호2
|
| 소속 |
1요업(세라믹)기술원 / 고려대, 2요업(세라믹)기술원 |
| 키워드 |
L3 |
| E-Mail |
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| 원문파일 |
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