| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.373 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Characteristics of Novel Biodegradable 3MA Bone Cements Containing Lactide-based Oligomers |
| 초록 | The main function of bone cement is to stabilize prosthesis by filling the gap between the prosthesis and the surrounding bone and to transmit loads from the prosthesis the bone. poly(methylmethacrylate) (PMMA) bone cement, which was widely used in orthopedic surgery, has no ability for bone bonding, leading to aseptic loosening of the cement, caused by both mechanical and biological factors. In order to solve these problems, several biodegradable bone cements with normal bone healing and remodeling processes and improved physical properties have been developed. Biodegradable bone cements present many advantages over PMMA by providing initial structural support, and then by resorbing in a controlled fashion and allowing ingrowth and remodeling by normal host bone1. In the present study, we have prepared the novel biodegradable bone cements containing Bis-GMA and its derivatives (3MA and 3MA mixture) as prepolymer, lactide-based oligomers (GL7, GL15, GL7-Ac, and GL15-Ac) as additive, and AW-GC as bioactive ceramic filler. As compared with Bis-GMA control, the novel biodegradable bone cements with an appropriate ratio of polymerization initiator (BPO), promoter (DMPT), and inhibitor (HQ) were characterized by evaluating curing time, polymerization shrinkage, as well as mechanical properties. Fig. 1 showed typical compressive strengths of some biodegradable bone cements. 3MA bone cement containing GL7-Ac 10 wt% displayed the highest compressive strength among the tested samples. In addtion, the biodegradation and bioactivity behaviors of these bone cements are demonstrated. Fig. 1. Compressive strengths of biodegradable bone cements. Reference 1. D. D. Frazier, V. K. Lathi, T. N. Gerhart, and W. C. Hayes, J. Biomed. Mater. Res., 35, 383 (1997). |
| 저자 | 김지은1, 안광덕1, 김종만2, 한동근1 |
| 소속 | 1한국과학기술(연), 2한양대 |
| 키워드 | bone cement; 3MA; biodegradation; lactide oligomer |
