| 초록 |
The polymeric material made with poly(lactic acid)/poly(ethylene glycol)(PLE) were prepared using copolymer of D,L-lactide and poly(ethylene glycol) for application of drug delivery systems. Catalyst made use of stannous octoate. Preparation of nanoparticles by dialysis method and solvent evaporation method that nanoparticle made use of according to solvent of various kinds. Empty particle size preparation by dialysis method and solvent evaporation method were differ greatly(32.4±7.9～535.9±283.7), (33.6±26.4～245.6±136.0), respectively. Moreover, drug loaded particle size were differ greatly(51±4.9～761.9±189.3),(54.8±39.0～832.1±920.3), respectively. Particle size, drug loading, and drug release rate of PLE-2 nanoparticles were slightly changed by the used initial solvents. The degradation behavior of PLE block copolymer nanoparticles has divided three phases, initial rapid degradation phase, stationary phase, and rapid degradation phase until complete degradation. It was suggested that adriamycin release kinetics was dominantly governed by diffusion mechanism at initial burst phase and, after that, both of diffusion and degradation mechanism.
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