| 초록 |
Hyperthermia, the artificially induced heat treatment of a disease, uses temperatures ranging between 42 °C and 47 °C. Generally, a temperature below 45 °C induces apoptotic cell death. However, achieving effective apoptotic hyperthermia is often difficult, as cells typically acquire resistance to induced thermal stress. Highly efficient apoptotic hyperthermia is achieved using a double-effector nanoparticle that can generate reactive oxygen species (ROS) and heat. ROS render cancer cells more susceptible to subsequent heat treatment, which remarkably increases the degree of apoptotic cell death. |
