| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
대학원생 구두발표(발표10분) |
| 제목 |
pH-responsive Eudragit® nanofiber for anti-bacterial activity by controlled release of tetracycline |
| 초록 |
Electrospun nanofibrous mats for pH-dependent anti-bacterial activity were fabricated with two Eudragit® polymers with opposite charges. Eudragit® EPO (EEPO) having dimethylamino group and Eudragit® L100 (EL100) having carboxylate were co-electrospun with tetracycline (Tet) and subsequently complexed at the tip of co-axial needle during the electrospinning process. The composition of the respective polymer was conveniently adjusted by changing the flow rate ratios of EL100 (outlet) and EEPO (inlet). In pH 2.0 buffer, NF with higher EEPO contents was dissolved rapidly. Also, higher EEPO composition in NF accelerated release of Tet in pH 2.0 and pH 6.0. The release fractions from higher EEPO composition NF was more successfully inhibited the growth of E.coli in pH2 and pH6. In conclusion, the Eudragit® nanofiber was successfully controlled the release of Tet by complexation of oppositely-charged EL100 and EEPO. |
| 저자 |
김영희, 유혁상
|
| 소속 |
강원대 |
| 키워드 |
nanofiber; antibacterial; drug release
|
| E-Mail |
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