| 학회 | 한국재료학회 |
| 학술대회 | 2013년 가을 (11/06 ~ 11/08, 제주롯데호텔) |
| 권호 | 19권 2호 |
| 발표분야 | 제25회 신소재 심포지엄-조직재생 및 생체재료 심포지엄 |
| 제목 | 재내피화를 위한 내피전구세포 특이적 금속스텐트 개발Endothelial Progenitor Cells-Specific Metallic Stent Modifications for Enhanced Endothelialization: Delivery or Recruit Progenitors? |
| 초록 | In recent several decades, in-stent restenosis and thrombosis have been still major reasons of clinical failure. The fundamental solution of such failures is well known to restore damaged endothelium, named endothelialization. In this study, we focused on functionalizing surface of metallic stent by mimicking natural healing mechanism of damaged endothelium. For the aim of this study, three different strategies were tried as follows. As the first strategy, stent surface was modified with in vitro manipulated extracellular matrices for the delivery of endothelial progenitor cells. Second strategy is that stent surface is modified with LbL technology for recruiting endogenous endothelial progenitors. Finally, stent surface is modified with oriented antibody immobilization for capturing circulating endothelial progenitors. These strategies may be fundamental breakthrough of stenting failure that is caused by in-stent restenosis and thrombosis. References [1] Daemen J et al., " Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: data from a large two-institutional cohort study", Lancet, Vol. 369, Issue 9562, 2007, pp. 667-678. [2] Sigwart U, Puel J, Mirkovitch V, Joffre F, Kappenberger L, “Intravascular stents to prevent occlusion and restenosis after transluminal angioplasty”, New Eng J Med, 1987, Vol. 316, No. 12, pp. 701-706. [3] Eggermann J, Kliche S, Jarmy G, Hoffmann K, Mayr-beyrle U, Debatin, K-M, Waltenberger J, Beltinger C, “endothelial progenitor cell clutlre and differentiation in vitro: a methodological comparison using human umbilical cord blood” Cardiovas Res, 2003, Vol. 53, No. 2, pp. 478-486. [4] Lim W-H, Seo W-W, Choe, W, Kang C-K, Park J, Cho H-J, Kyeong S, Hur J, Yang H-M, Cho H-J, Lee Y-S, Kim H-S, “Stent Coated With Antibody Against Vascular Endothelial-Cadherin Captures Endothelial Progenitor Cells, Accelerates Re-Endothelialization, and Reduces Neointimal Formation”, Arterioscl Thromb Vasc Biol, 2011 Vol. 31, pp. 2798-2805. |
| 저자 | 정윤기1, 강성남2, 민일재3, 한동근1 |
| 소속 | 1한국과학기술(연), 2의공학(연), 3생체재료연구단 |
| 키워드 | metallic stent; endothelialization; endothelial progenitor; surface modification; outgrowth endothelial cell |
