| 초록 |
Controlling the morphology is critical to the catalytic performance and therapeutic effect of ceria nanoparticles. Herein, the therapeutic outcomes of ceria nanorods (Ceria NRs) and ceria nanospheres (Ceria NSs) were investigated and compared in an in vivo study of mild traumatic brain injury (mTBI). Ceria nanoparticles significantly reduced FJB-positive cells and TUNEL-positive cells, and restored mRNA levels of SOD1 and SOD2. They also decreased COX-2 expression compared with the untreated control group. Comparing the two nanomaterials, Ceria NRs showed less stable and high-energy (100) and (110) planes, which increased the number of active sites. Ceria NRs (70.1 ± 0.5%) significantly decreased brain water content compared with Ceria NSs (73.7 ± 0.4%; p=0.0015), indicating that Ceria NRs are more effective in alleviating cerebral edema following in vivo mTBI. |
