| 초록 |
A cancer-selective probe and drug delivery system was developed by loading disulfide-modified carbon dot (CD) onto manganese oxide (MnO2) nanosheet, followed by loading paclitaxel (PTX). High fluorescence CD was synthesized via carbonization process of disulfide cross-linked hyaluronic acid and further loaded onto MnO2 nanosheets, causing fluorescence quenching of CD. The resulting CD-PTX@MnO2 was further cleaved in the presence of glutathione (GSH) in cancer cell due to reduction of MnO2 and disulfide bond, allowing recovery of fluorescence and release of PTX in cancer cell. Furthermore, CD-PTX@MnO2 demonstrated good biocompatibility towards normal cells and high selectivity towards tumor cells, indicating this system was suitable for cancer targeting both in bioimaging and chemotherapy. Thus, this system provides promising strategy for highly selective cancer bioimaging and smart drug delivery system. This work was supported by Korea National University of Transportation in 2019. |
