| 학회 | 한국공업화학회 |
| 학술대회 | 2014년 가을 (11/12 ~ 11/14, 엑스코(대구)) |
| 권호 | 18권 2호 |
| 발표분야 | 생물공학-포스터 |
| 제목 | Development of small molecule-peptide conjugates as novel whitening agents, and improvement of their photostability |
| 초록 | In previous study, we developed small molecule-peptide conjugates as potential whitening agents which inhibit tyrosinase activity and antagonize MC1R at the same time. The conjugated small molecules having tyrosinase inhibitory activity were selected using mushroom tyrosinase assay. Through this method, caffeic acid and p-coumaric acid were screened. However, these conjugates were unstable under UV light because of oxidation of their hydroxyl group. In this study, we developed photostabilized small molecule-peptide conjugates, and their potentials as skin whitening agents were investigated. Acknowledgement This study was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea.(Grant No. HN10C0006) |
| 저자 | 이혜숙1, 이재호2, 김재일2, 조인식1, 김한영1 |
| 소속 | 1애경산업, 2광주과학기술원 |
| 키워드 | Peptide; Tyrosinase; Anti-melanogenic activity; photostability |
