| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
The preparation of BSA-loaded microcapsules for Drug Delivery System |
| 초록 |
The sustained and controlled protein release as well as long term pharmacological duration of protein activity is very important in the development of practical drug delivery system. In this study, we prepared BSA-loaded microcapsules, consisting of BSA core inside a PLGA shell, varying a number of parameters to determine optimal conditions using a monoaxial ultrasonic atomizer. BSA encapsulation efficiency of ~60% and a particle size of ~50 micrometer. And injection of BSA-FITC-loaded microcapsules into rats resulted in a sustained release of BSA-FITC in plasma for up to 2 weeks. We believe the results of the present study provide new options for sustained in vivo release of highly potent therapeutics, and represent a useful experimental platform for future protein delivery research. Acknowledgements: This study was supported by a grant from MKE (Grant no. 10030022). |
| 저자 |
이상효1, 오재민2, 손진수3, 이봉3, 김재호1, 이해방2, 김문석1
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| 소속 |
1아주대, 2한국화학(연), 3부경대 |
| 키워드 |
microcapsules; drug delivery system
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| E-Mail |
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