| 초록 |
Extracellular vesicle(EV) has highlighted as a therapeutic nanomedicine to intractable diseases because it plays an essential role in cell-to-cell communications. However, their poor circulation properties limit the therapeutic potential of EVs. To overcome this issue, we developed surface-engineered EVs(S-EVs) based on the modification of EV-donor cell surfaces. The S-EVs were prepared by ultracentrifugation and characterized by nanoparticle tracking analysis, flow cytometry, and transmission electron microscopy. Notably, they showed enhanced targeting efficiency for tumor and rheumatoid arthritis mice models compared to control EVs owe to not only a passive- but also an active-targeting process. These results suggest the methodology to engineered exosome surface as a powerful tool for targeting intractable diseases. |
