| 초록 |
Sequence-defined polymers are interesting synthetic targets for polymer chemists. The challenge lies in the development of synthetic procedures to ensure the structural definition during the course of repeated synthetic steps to achieve high molecular weight. We show a repetitive synthesis of poly(β-amino ester), a well-known cationic polymers to construct complexes with DNA, in a sequence defined manner. The repeating steps of Michael addition and esterification of monomers are conducted on a monodisperse oligo(ethylene glycol) support. To increase the molecular weight without losing the structural definition, we investigate the iterative growth of oligo(β-amino ester) fragments. The coupling strategy to accommodate functional groups is also investigated. The resulting monodisperse oligomers of PEG-poly(β-amino ester) can be a model amphiphile to develop new materials for biocompatible materials for gene delivery. |
