| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 |
19권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Skin patch immobilized with VEGF-incorporated hydrogel for wound healing applications |
| 초록 |
As the largest organ, skin covers the entire exterior of the body. Due to its direct exposure to potentially harmful reagents, the loss of skin can occur for many reasons. Tissue engineered skin substitute represent a logical therapeutic options for the treatment of acute and chronic wounds. In this work, porous polyester fabrics were rendered to have Janus property via initiated chemical vapor deposition (iCVD) of a flouropolymer. Antimicrobial property of hydrophobic surface was confirmed by bacterial cell adhesion and proliferation analysis. Simple hydrolysis reaction with KOH on thin film of flouropolymer resulted in hydrophilic carboxylic acid functionality, which were further chemically reacted to immobilize gelatin methacrylate(GelMA) and growth factors. The porous polyester fabric immobilized with VEGF-incorporated GelMA along with its antimicrobial property can be potentially applied in various skin regeneration applications. |
| 저자 |
안영현1, 유승정2, 임현구1, 임성갑2, 황석연1
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| 소속 |
1서울대, 2KAIST |
| 키워드 |
Initiated chemical vapor deposition(iCVD); hydrogel immobilization; gelatin methacrylate; wound healing; protein delivery
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| E-Mail |
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