| 초록 |
This is the cooling crystallization about different solvent concentration rate of API(Active Pharmaceutical Ingredients). API has different physical and chemical characteristic, so prior to cooling process, the solubility experiment is necessary for control this in crystallization. In the search of API solubility about IPA-Methanol solvent, the higher concentration of solvent and higher temperature, the higher solubility. In this experiment, the cooling crystallization proceeds on the basis of this API solubility data. The polymorph of API is in real-time analyzed by using Raman. The API 1 changes the form at 25 minute. And the API 2 changes between 3 hour and 8 hour. |
