| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.348 |
| 발표분야 | 고분자 구조 및 물성 |
| 제목 | The Ion-Gating Mechanism in Membrane Protein: an Atomistic Molecular Dynamics Simulation of Cl– Conduction in ClC Channel |
| 초록 | ClC channels are Cl–-selective ion channels that are found in various kinds of organisms from bacteria to humans. In the case of humans, it is known that nine isoforms of ClC channels are involved in various physiological functions, such as the control of the resting potential in muscle and neurons and the acidification process in intracellular organisms. Malfunction and mutation of these channels cause fatal diseases such as myotonias, some types of epilepsy, nephrophathies and osteopetrosis. The most interesting function of ClC ion channels is gating, which refers to opening and closing the pore, i.e., the process by which ion conduction is turned on or off. Recent success in structural determination of bacterial ClC channel provides us with important insight into the gating mechanism of ClC ion channel. However, the detailed description about the mechanism of the gating is still far from a complete realization. The present work seek to elucidate the molecular origins of the gating mechanism in ClC channel using an atomistic molecular dynamics combined with a perturbation theory. |
| 저자 | 고연조, 허준, 조원호 |
| 소속 | 서울대 |
| 키워드 | ClC; ion channel; ion conduction; MD; molecular dynamics; simulation |
