| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
대학원생 구두발표(발표10분) |
| 제목 |
Surface Enhanced Raman Scattering-fluorescence Dual Nanoprobes for Multiplexed Detection of Pathogens |
| 초록 |
Surface-enhanced Raman scattering (SERS) has been of growing interest for detection of pathogens without any labeling. In this study, we report that SERS-fluorescence (FL) based dual nanoprobes in the form of hierarchical nanostructures with metallic nanoparticle clusters (MNPCs) were prepared and used along with magnetic beads (MBs) for fast and multiplexed detection of bacterial pathogens. Both MNPCs with different Raman dyes and two sets of fluorescence dyes were simultaneously encapsulated within polymeric nanoparticles using electrohydrodynamic (EHD) jetting. Two different sets of antibodies against two kinds of bacterial pathogens were separately conjugated with the dual nanoprobes and the MBs, respectively. They showed excellent capability of fast and multiplexed detection of bacterial pathogens using SERS-FL dual signals. Conclusively, the SERS-FL dual nanoprobes in the form of hierarchical nanostructures with MNPCs open a new avenue for multiplexed biodetection. |
| 저자 |
장홍덕1, 정찬우2, 최종훈3, 주재범1, 임동우2
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| 소속 |
1Department of Bionanotechnology, 2Hanyang Univ., 3ERICA Campus |
| 키워드 |
Surface Enhanced Raman Scattering; Fluorescence; Dual nanoprobes; Multiplexing; Pathogen detection
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| E-Mail |
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